Posts Tagged ‘scientific studies’

New M2 Petitions on Horizon Again

January 23rd, 2013

Last January we accepted petitions from the public to add PTSD 1PTSD 2; Depression; Migraines; and Generalized Anxiety Disorder to the list of conditions that qualify patients to receive a Medical Marijuana Registration Card.  Because my guiding principle for making the decision was to use science and research to make the decision, we contracted with the U of A College of Public Health to do an evidence review of published scientific studies to help us to make a more informed decision.  You can see the UA’s analyses for Depression; Generalized Anxiety Disorder; Migraine Headaches; and Post Traumatic Stress Disorder (PTSD) on our petition website.   Our literature review found limited scientific evidence to document whether Cannabis is helpful or not for the petitioned conditions or that support permanently adding the petitioned conditions to the statutory list of qualifying debilitating conditions identified in the Act.  In short- I didn’t approve the petitions last year because of the lack of published data regarding the risks and benefits of using Cannabis to treat or provide relief for the petitioned conditions. 

The AZ Medical Marijuana Act requires us to periodically accept petitions to add new medical conditions- and we are once again accepting petitions to add new debilitating medical conditions this week (January 25 – 31) on our petition website. Our medical team will meet after January 31st and will be providing me with an initial analysis regarding whether any petitions we receive meet the screening criteria…  and we’ll be using the UA College of Public Health to review the scientific literature for any that pass the screening test.  Assuming we receive qualified petitions, I’ll need to make a final decision by July 2013.  Our website shows folks how, what, where, and when to submit petitions.

GRADEing Studies & Evidence

July 19th, 2012

As I mentioned in my previous post, scientific studies (e.g. experimental v. observational design) have different strengths and weaknesses. Sources of evidence range from case reports at the lower end to well-designed large randomized experimental clinical studies that minimize bias.  Relying on poor quality evidence can lead to policy decisions that aren’t in patients’ best interests- and it’s super important to figure out the actual “weight of evidence” that published studies provide- so public health can make good evidence-based decisions. 

That’s where the Grading of Recommendations Assessment, Development and Evaluation- or GRADE system comes in.  The GRADE system was developed to provide researchers and policy makers a systematic way of grading the strength of studies to help policy makers in medicine and public health to interpret studies and make better decisions.  The GRADE system has all kinds of applications.  For example, the U of A used the GRADE methodology to evaluate the quality of the studies looking at the benefits and harms of using Cannabis to treat the conditions that were petitioned to add to the list of qualifying conditions for a medical marijuana card.

You can read alot more about the GRADE system and how it works in this article in the British Medical Journal (unfortunately you need to pay to read the whole thing).